This study reveals that apple juice can be a useful supplement for calming the declining moods that are part of the normal progression of moderate-to-severe Alzheimer’s Disease. After institutionalized AD patients consumed two 4-oz glasses of apple juice a day for a month, their caregivers reported no change in the patients’ Dementia Rating Scale or their day-to-day abilities. What did change, however, was the behavioral and psychotic symptoms associated with their dementia with approximately 27% improvement, mostly in the areas related to anxiety, agitation, and delusion. The statistically significant impact of apple juice on the behavioral and psychological symptoms of dementia in this study adds to the body of evidence supporting the usefulness of nutritional approaches, including fruit and vegetable juices, in delaying the onset and progression of Alzheimer’s Disease.
Preclinical studies demonstrate that apple juice exerts multiple beneficial effects including reduction of central nervous system oxidative damage, suppression of Alzheimer’s disease (AD) hallmarks, improved cognitive performance, and organized synaptic signaling. Herein, we initiated an open-label clinical trial in which 21 institutionalized individuals with moderate-to-severe AD consumed 2 4-oz glasses of apple juice daily for 1 month. Participants demonstrated no change in the Dementia Rating Scale, and institutional caregivers reported no change in Alzheimer’s Disease Cooperative Study (ADCS)-Activities of Daily Living (ADL) in this brief study. However, caregivers reported an approximate 27% (P < .01) improvement in behavioral and psychotic symptoms associated with dementia as quantified by the Neuropsychiatric Inventory, with the largest changes in anxiety, agitation, and delusion. This pilot study suggests that apple juice may be a useful supplement, perhaps to augment pharmacological approaches, for attenuating the decline in mood that accompanies progression of AD, which may also reduce caregiver burden.
Remington, R., Chan, A., Lepore, A., Kotlya, E., & Shea, T. (2010). Apple Juice Improved Behavioral But Not Cognitive Symptoms in Moderate-to-Late Stage Alzheimer’s Disease in an Open-Label Pilot Study American Journal of Alzheimer’s Disease and Other Dementias, 25 (4), 367-371 DOI: 10.1177/1533317510363470