Studies have shown that the UK population is becoming increasingly skewed towards older adults,1 and that this trend is likely to continue in the future. Concomitantly, increasing levels of obesity have led to predictions that 700 million people worldwide will be obese by 2015. Whilst these increases in obesity rates have been observed, there has been a relative dearth of novel therapies being developed to tackle obesity. Basic laboratory experiments have shown that by severely restricting calorie intake one can not only induce weight loss but can also influence the ageing process. This review critically evaluates the benefits of these dietary interventions on age-related decline and longevity.
Excess calorie consumption is associated with metabolic disorders and increased incidence of morbidity. Restricting calorie content, either by daily calorie restriction or intermittent fasting periods, has multiple benefits including weight loss and improved body composition. Previous research has shown that restricting calories in this way can increase longevity and slow the ageing process in laboratory animals, although only sparse data exist in human populations. This review critically evaluates the benefits of these dietary interventions on age-related decline and longevity.
James E Brown
Can restricting calories help you to live longer? Post Reprod Health March 2014 20: 16-18, doi:10.1177/1754045314521553