Category Archives: Medicine

Mozobil: From anti-HIV agent to stem cell mobilizer

How was a stem cell mobilizer, which can be applied in the treatment of diseases such as Non-Hodgkin’s lymphoma, discovered? The demonstration of the stem cell mobilizing potential of AMD3100 (plerixafor, or Mozobil) was the result of a series of … Continue reading

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On SAGE Insight: Prenatal and perinatal risk factors and the clinical implications on autism spectrum disorder

From Autism Autism spectrum disorder (ASD) is a multi-factorial neurodevelopmental disorder that afflicts approximately 1 in 68 children in the United States and 1 in 100 children in Taiwan.  The development of ASD is associated with a sophisticated collection, both … Continue reading

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On SAGE Insight: Description and Burden of Dementia and Mild Cognitive Impairment

Article title: The Cretan Aging Cohort: Cohort Description and Burden of Dementia and Mild Cognitive Impairment From American Journal of Alzheimer’s Disease & Other Dementias® The aim of this study was to explore the burden of dementia in the Cretan … Continue reading

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On SAGE Insight: What’s the harm in mixing alcohol and drugs? A lot, apparently!

In a recent study that Dr. Meenakshi Subbaraman and I published with colleagues in the journal Nordic Studies on Alcohol and Drugs, we found that U.S. adults who use alcohol and drugs at the same time are more likely to … Continue reading

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On SAGE Insight: New recommendations for chronic breathlessness care

New recommendations for services for people living with chronic breathlessness in advanced disease have been developed and prioritised by people from a variety of professions and disciplines, including patient and carer representatives. Their recommendations emphasise the need for improved access … Continue reading

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On SAGE Insight: Why are there ethnic differences in cardio-metabolic risk factors and cardiovascular diseases?

The population of Europe has become increasingly more ethnically diverse with an estimated 55% of residents in urban London originating from non-White British backgrounds. Studies investigating populations of various ethnic backgrounds have found the risk of developing heart disease, diabetes, … Continue reading

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On SAGE Insight: Using beef cattle to learn more about obesity and pulmonary hypertension in humans

The increased occurrence of both adult and juvenile overweight and obese individuals, termed the “obesity epidemic” in the US and other developed nations, has been accompanied by attendant increases in cardiovascular disease. The consequences of the Western diet on systemic … Continue reading

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On SAGE Insight: Why are African Americans more susceptible to acute respiratory distress syndrome?

Acute respiratory distress syndrome (ARDS) is a vexing critical care illness in patients with respiratory failure. A fundamental pathobiological feature of ARDS is an increase in blood vessel permeability, and the permeability of its lining, resulting in excessive fluid leakage … Continue reading

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On SAGE Insight: Insights on the Latest Attack Vectors (and Security Controls) for Medical Device Applications

From Journal of Diabetes Science and Technology As medical devices gain the same kind of pervasive network and Internet connectivity that permeates the rest of our world today, patient care has never been better. The interconnectedness of implantable, wearable and, … Continue reading

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On SAGE Insight: Pharmacotherapy of type 1 diabetes in children and adolescents: more than insulin?

For pediatric patients with type 1 diabetes, intensified insulin therapy, with either multiple daily injections or insulin pump therapy, is currently the only method of treatment. To optimize this therapy, insulin analogues are fixed parts of all therapy regimens. Analogue … Continue reading

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On SAGE Insight: 4 free must-read journal articles to mark World Stroke Day 2018

Some great free reads on Stroke issues covering prevention programs, food management, disability, infection risk and more…  Journal articles: Cut stroke in half: Polypill for primary prevention in stroke International Journal of Stroke, DOI: 10.1177/1747493018761190, First Published February 20, 2018 … Continue reading

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On SAGE Insight: Blog Posts from SAGE Open Access in 2018

In 2018, open access journals at SAGE began experimenting with a new style of blog post, to aid authors in reaching new audiences with their research. These new blog posts allow the author to summarise one or more of the … Continue reading

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On SAGE Insight: Unpublished Alan Turing studies could provide an alternative to the evaluation of diagnostic tests

Article title: Quantifying performance of a diagnostic test as the expected information for discrimination: Relation to the C-statistic From Statistical Methods in Medical Research We are entering a new era of “precision medicine” where prevention and treatment is based on tests that … Continue reading

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On SAGE Insight: Marking Blood Cancer Awareness Month: Toward a Biology-Driven Treatment Strategy for Peripheral T-cell Lymphoma

From Clinical Medicine Insights: Blood Disorders To mark Blood Cancer Awareness Month 2018, SAGE is delighted to offer free access to this great article on SAGE Insight. T-cell and natural killer–cell lymphomas are a relatively rare and heterogeneous group of … Continue reading

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On SAGE Insight: Audio Description in the UK: What works, what doesn’t, and understanding the need for personalising access

From British Journal of Visual Impairment Audio Description for film and television is a pre-recorded track that uses verbal descriptions to provide information on visual aspects of a film or TV programme. In the UK, it is currently the only … Continue reading

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